Published November 2005
| Version v1
Journal article
Comparison of Na188ReO4, 188Re-DTPA and 188Re-MAG3 on biodistribution and excretion of animal
Creators
- 1. China Inst. of Atomic Energy, Beijing (China). Dept. of Isotopes
- 2. Beijing Univ. Medical Isotopes Research Center, Beijing (China)
Description
In order to screen out an ideal radioactive agent for preventing the restenosis after PTCA (Percutaneous Transluminal Coronary Angioplasty), Na188ReO4, 188Re-DTPA and 188Re-MAG3 are injected into ICR mice and SD rats to compare the biodistribution and excretion. The experimental data show that the blood clearance of 188Re-MAG3 is much faster, and the uptake in tissues is obviously lower than Na188ReO4 and 188Re-DTPA. Ar 2 h after injection, 77.28% of injection dose of 188Re-MAG3 is excreted from urine, whereas less than 50% for Na188ReO4 and 188Re-DTPA. So, 188Re-MAG3 is a better candidate for balloon dilation providing uniform endovascular irradiation following PTCA for restenosis therapy. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Isotopes
- Journal Volume
- 18
- Journal Issue
- 4
- Journal Page Range
- p. 207-210
- ISSN
- 1000-7512
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 37103621
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD; CARDIOVASCULAR DISEASES; CORONARIES; DTPA; EXCRETION; MICE; PERRHENATES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RADIOTHERAPY; RATS; RHENIUM 188; SODIUM COMPOUNDS; TISSUE DISTRIBUTION; UPTAKE; URINE
- Descriptors DEC
- ALKALI METAL COMPOUNDS; AMINO ACIDS; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD VESSELS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; CHELATING AGENTS; CLEARANCE; DISEASES; DISTRIBUTION; DRUGS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLOGY; RADIOPROTECTIVE SUBSTANCES; REFRACTORY METAL COMPOUNDS; RESPONSE MODIFYING FACTORS; RHENIUM COMPOUNDS; RHENIUM ISOTOPES; RODENTS; THERAPY; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; WASTES
Optional Information
- Notes
- 1 fig., 1 tab., 15 refs.