Published September 1995 | Version v1
Journal article Metadata-only

The effect of dose rate on induction of chromosome aberrations and lung tumor in mice under combined influence of ionizing radiation and chemical agents

Creators

Description

In the experiment with combined influence of single or prolonged gamma-irradiation (35 cGy) and chemical agents (urethanum, nitrogen oxide) on the induction of chromosome aberrations in bone marrow cells and lung tumor the effect of dose rate was studied. The frequency of chromosome aberrations increased with dose rate. Yet the correlation between the ratio of unrepairable (stable) aberrations and dose rate was of inverse direction. The character of variations in lung adenoma frequency under multifactor influence in the case of prolonged irradiation (increase with dose rate decrease) supports the correlation between the level of stable aberrations in the pool of genetic lesions and the frequency of lung adenoma. 20 refs.; 3 tabs

Additional details

Additional titles

Original title (Russian)
Влияние мощности дозы на индукцию хромосомных аберраций и опухолей легких у мышей при слчетанном действии ионизирующего излучения и химических веществ

Publishing Information

Journal Title
Radiatsionnaya Biologiya, Radioehkologiya
Journal Volume
35
Journal Issue
5
Journal Page Range
p. 777-785.
ISSN
0869-8031
CODEN
RBIREJ

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
27050710
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ADENOMAS; BONE MARROW CELLS; CHROMOSOMAL ABERRATIONS; CHRONIC IRRADIATION; DOSE RATES; GAMMA RADIATION; INDUCTION; LUNGS; MICE; NITROGEN OXIDES; TEMPORAL DOSE DISTRIBUTIONS; URETHANE
Descriptors DEC
ANIMAL CELLS; ANIMALS; BODY; CARBAMATES; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACID SALTS; CARCINOMAS; CHALCOGENIDES; CHRONIC EXPOSURE; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MUTATIONS; NEOPLASMS; NITROGEN COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; RADIATION DOSE DISTRIBUTIONS; RADIATIONS; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; VERTEBRATES