Metastases or benign adrenal lesions in patients with histopathological verification of lung cancer: Can CT texture analysis distinguish?

Highlights: In a lung cancer population, • Adrenal CTTA cannot discriminate benign from malignant lesion, despite several CTTA parameters differed between metastatic and benign lesions. • The optimal model based on multivariate logistic regression showed AUC of 73 %. • The use of adrenal CTTA cannot be recommended in clinical decision making. Distant metastases are found in the many of patients with lung cancer at time of diagnosis. Several diagnostic tools are available to distinguish between metastatic spread and benign lesions in the adrenal gland. However, all require additional diagnostic steps after the initial CT. The purpose of this study was to evaluate if texture analysis of CT-abnormal adrenal glands on the initial CT correctly differentiates between malignant and benign lesions in patients with confirmed lung cancer.