Published November 1988 | Version v1
Journal article Metadata-only

The influence of ursodeoxycholic acid on hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan in chronic liver diseases

Creators

  • 1. Nagoya City Univ. (Japan). Faculty of Medicine

Description

Hepatobiliary scintigraphy using 99mTc-N-pyridoxyl-5-methyltryptophan (PMT) was used to elucidate the effect of ursodeoxycholic acid (UDCA) treatment on chronic liver diseases. After UDCA administration, the peak of the hepatic uptake-excretion curve of 99mTc-PMT (peak time) was significantly shortened. Serum γ-GTP level also improved during UDCA therapy. These results suggest that UDCA enhances uptake especially of anions like 99mTc-PMT, and increases their secretion into bile. Consequently, UDCA may be pharmachologically useful for chronic liver diseases. (author)

Additional details

Publishing Information

Journal Title
Nippon Shokakibyo Gakkai Zasshi
Journal Volume
85
Journal Issue
11
Series
Nippon Shokakibyo Gakkai Zasshi.
Journal Page Range
2389-2395
ISSN
0369-4259
CODEN
NIPAA

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
20034277
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BILIARY TRACT; BIOLOGICAL FUNCTIONS; CHOLIC ACID; EXCRETION; HEPATITIS; LIVER; PATIENTS; SCINTISCANNING; TECHNETIUM 99; TRYPTOPHAN; UPTAKE
Descriptors DEC
AMINO ACIDS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BILE ACIDS; BODY; CARBOXYLIC ACIDS; CLEARANCE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; GLANDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INDOLES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOISOTOPE SCANNING; RADIOISOTOPES; STEROIDS; STEROLS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES