Published 2011
| Version v1
Book
Specific labelling of a leukotriene biosynthesis inhibitor MK-886 with tritium radioisotope
Creators
- 1. Labelled Compounds, Immunoassay Labelled Compounds and Jonaki, Board of Radiation and Isotope Technology, Navi Mumbai (India)
Description
This paper describes a convenient procedure for the specific labelling of MK-886. 1-(4-chloro- (3- 3H) benzyl)- 3- ( t-butylthio) - α, α - dimethyl -5- (isopropyl)- indole-2- propanoic acid (MK-886) of specific activity 13,700 mCi/mmole 506.9 GBq/mmole). The radiolabelled agent was prepared by catalytic dehalogenation of 1-(4-chloro- 3-iodo benzyl)-3-(t- butylthio)- α, α - dimethyl -5- (isopropyl)- indole-2- propanoic acid with tritium gas under controlled conditions. (author)
Additional details
Publishing Information
- Publisher
- Bhabha Atomic Research Centre
- Imprint Place
- Mumbai (India)
- Imprint Title
- Proceedings of DAE-BRNS symposium on nuclear and radiochemistry. V. 2
- Imprint Pagination
- 371 p.
- Journal Page Range
- p. 599-600
Conference
- Title
- 10. symposium on nuclear and radiochemistry
- Acronym
- NUCAR 2011
- Dates
- 22-26 Feb 2011
- Place
- Visakhapatnam (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 42074240
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- APOPTOSIS; CHROMATOGRAPHY; DNA; RADIOCHEMICAL ANALYSIS; RADIOPHARMACEUTICALS; TRITIUM
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; DRUGS; HYDROGEN ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 5 refs., 2 figs.