Published 1988 | Version v1
Book Metadata-only

Quantitative evaluation of coronary blood flow by PET in the human heart

Creators

Description

Conventional nuclear medicine procedures such as T1-201 scintigraphy allow only qualitative assessment of regional myocardial blood flow. PET provides attenuation-corrected images of myocardial tracer distribution and thus the potential for quantitative measurement of tracer kinetics. Dynamic PET imaging with high temporal resolution (10 sec/frame) after intravenous injection of the blood flow tracer N-13 ammonia was applied to seven healthy human subjects at rest and after intravenous dipyradamole. A three-compartmental tracer kinetic model was used to fit regional myocardial time-activity curves yielding estimates of blood flow and rate constants for tracer retention. At rest, blood flow averaged 64 +- 10 mL/min/100 g and increased after intravenous application of dipyridamole to 274 +- 84 mL/min/100 G. These PET values agree well with invasively measured coronary blood flow

Additional details

Publishing Information

Publisher
Radiological Society of North America Inc.
Imprint Place
Oak Brook, IL (USA)
Imprint Title
Radiological Society of North America 74th scientific assembly and annual meeting (Abstracts)
Imprint Pagination
395 p.
Journal Page Range
p. 313.

Conference

Title
74. scientific assembly and annual meeting of the Radiological Society of North America (RSNA).
Dates
27 Nov - 2 Dec 1988.
Place
Chicago, IL (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
21002974
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AMMONIA; BLOOD FLOW; CORONARIES; DIAGNOSIS; FEASIBILITY STUDIES; HEART; IMAGE PROCESSING; INTRAVENOUS INJECTION; NITROGEN 13; PATHOLOGICAL CHANGES; POSITRON COMPUTED TOMOGRAPHY; SCINTISCANNING; THALLIUM 201
Descriptors DEC
ARTERIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HEAVY NUCLEI; HYDRIDES; HYDROGEN COMPOUNDS; INJECTION; INTAKE; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; POLAR SOLVENTS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SOLVENTS; THALLIUM ISOTOPES; TOMOGRAPHY

Optional Information

Secondary number(s)
CONF-8811134--.