Published December 1992
| Version v1
Journal article
Preparation of [131I]lipiodol as a hepatoma therapeutic agent
- 1. National Tsinghua Univ., Hsinchu (Taiwan). Inst. of Nuclear Science
- 2. Taipei Veterans General Hospital, Taipei (Taiwan)
- 3. Academia Sinica, Taipei (Taiwan). Inst. of Biomedical Sciences
Description
An isotopic exchange method was used to label lipiodol with 131I. The labelling efficiency was > 92.5%, and the radiochemical purity of [131I]lipiodol was above 98% as determined by ITLC. The influencing factors e.g. the heating temperature, reaction, pH and storage conditions were studied and the optimum conditions were determined. In a pilot study injecting [131I]lipiodol for the treatment of hepatoma, about 70% of hepatoma patients had a response to the treatment with a reduction of α-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2-17 months). (author)
Additional details
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 43
- Journal Issue
- 12
- Journal Page Range
- p. 1431-1435.
- ISSN
- 0883-2889
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 24025823
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; HEPATOMAS; IODINE 131; ISOTOPIC EXCHANGE; LABELLING; LIPIODOL; OPTIMIZATION; PH VALUE; RADIOPHARMACEUTICALS; RADIOTHERAPY; TISSUE DISTRIBUTION
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARCINOMAS; CONTRAST MEDIA; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; DRUGS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; OILS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; OTHER ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; THERAPY