Effectiveness of ⁹⁰Sr-⁹⁰Y applicator combined with topical timolol maleate treatment for infantile superficial hemangiomas

Objective: To investigate the clinical efficacy and safety of ⁹⁰Sr-⁹⁰Y applicator combined with topical timolol maleate for infantile superficial hemangiomas. Methods: A total of 59 infants with hemangiomas were randomly divided into a study group (n = 33; ≤ 3 months, 15 cases; > 3 months, 18 cases) and a control group (n = 26; ≤ 3 months, 10 cases; > 3 months, 16 cases). The study group was treated with applicator combined with timolol maleate solution (0.5%) and the control group was treated with the same dose of ⁹⁰Sr-⁹⁰Y applicator combined with saline. Treatment effectiveness was compared between the two groups, and χ² test was used for statistical analysis. Adverse reaction was observed and recorded. Results: The effective rate was 18/18, and the cure rates were 14/15 (≤ 3 months)and 16/18 ( > 3 months) in the study group. The effective rates were 8/10 (≤ 3 months) and 11/16 (> 3 months), and the cure rates were 6/10 (≤ 3 months) and 9/16 (> 3 months) in the control group. Both the effective rate and cure rate of the study group were significantly higher than those of control group (χ² = 22.22 and 30.29, ≤ 3 months; χ² = 36.69 and 27.31, > 3 months; all P < 0.01). Significant adverse reaction was not found in both groups. Conclusion: ⁹⁰Sr-⁹⁰Y applicator combined with 0.5% solution of topical timolol maleate has a very high effective and cure rate for infantile superficial hemangiomas, without significant adverse reaction observed. (authors)