Behaviour of the 99mTc-complexes from derivates of imidodiacetic acid in rats
Creators
- 1. Rostock Univ. (German Democratic Republic). Radiologische Klinik
Description
The in vitro and in vivo behaviour of several 99mTc-complexes of derivates of the imidodiacetic acid was examined. Starting from the hydrophilic behaviour of the complexes, the following questions were to be investigated: (1) To which degree do ligands have an influence on renal excretion? (2) Can any indication of a mainly tubular secretion be possibly obtained? 12 compounds which were substituted on the phenyl ring by means of HO-, H3C-CO-CO-, HOOC- and HO3S were studied. Two complexes were found to yield a high renal excretion (between 70 and 80%). 131I-o-iodohippuric acid and 99mTc-DTPA were studied as reference substances using the same methods. However, indication of mainly tubularly secreted 99mTc-complexes could not be found. (author)
Additional details
Additional titles
- Original title (German)
- Tierexperimentelle Untersuchungen zum Verhalten der
Publishing Information
- Journal Title
- Medicina Nuclearis
- Journal Volume
- 1
- Journal Issue
- 2
- Series
- Med. Nucl.
- Journal Page Range
- 133-136
- ISSN
- 0863-1271
- CODEN
- MEDNU
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- German Democratic Republic
- INIS RN
- 20079147
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BILE; CARBOXYLIC ACIDS; EXCRETION; IMIDES; IN VITRO; RADIOPHARMACEUTICALS; RATS; RENAL CLEARANCE; RETENTION; TECHNETIUM COMPLEXES; TECHNETIUM 99; TISSUE DISTRIBUTION; URINE
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CLEARANCE; COMPLEXES; DISTRIBUTION; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES