Published November 1999
| Version v1
Journal article
Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders
Creators
- 1. Rijksuniversiteit Leiden (Netherlands). Div. of Nuclear Medicine
- 2. Department of Physics and Nuclear Medicine, City Hospital, Birmingham (United Kingdom)
- 3. Departement de Recherche et Imagerie, Pharmacologie et Physiologie, Service Hospitalier Frederic Joliot, Orsay (France)
- 4. Office de Protection contre le Rayonnements Ionisants, Le Vesinet (France)
- 5. Department of Clinical Oncology, Leiden University Medical Centre, Leiden (Netherlands)
Description
Detrimental effects on the thyroid of the developing fetus as a result of iodine-131 treatment for thyrotoxicosis of the mother in the first trimester of pregnancy are discussed. Dose estimations under typical clinical circumstances yield a fetal thyroid dose of 100- 450 Sv. This dose may increase considerably if the blood concentration of 131I in the mother remains high. Under such circumstances there may be fetal thyroid dysfunction, which can lead to severe abnormalities. (orig.)
Additional details
Publishing Information
- Journal Title
- European Journal of Nuclear Medicine
- Journal Volume
- 26
- Journal Issue
- 11
- Journal Page Range
- p. 1453-1457
- ISSN
- 0340-6997
- CODEN
- EJNMD9
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 31006463
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ENDOCRINE DISEASES; FETUSES; INTERNAL IRRADIATION; IODINE 131; PATIENTS; PREGNANCY; PRENATAL IRRADIATION; RADIATION DOSES; RADIONUCLIDE KINETICS; RADIOSENSITIVITY; RADIOTHERAPY; THYROID; WOMEN
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE GLANDS; FEMALES; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IRRADIATION; ISOTOPES; KINETICS; MAMMALS; MAN; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRENATAL EXPOSURE; PRIMATES; RADIOISOTOPES; THERAPY; VERTEBRATES
Optional Information
- Notes
- 28 refs.