Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts
Creators
- 1. Department of Physics, Soongsil University, Seoul 156-743 (Korea, Republic of)
- 2. Brain Disease Research Center, Ajou University School of Medicine, Suwon 443-749 (Korea, Republic of)
- 3. Department of Advanced Materials Engineering, Daejeon University, Daejeon 300-716 (Korea, Republic of)
- 4. Department of Pathology Lab of Oriental Medicine College, Daejeon University, Daejeon 300-716 (Korea, Republic of)
- 5. Department of Electrical Engineering and Bioscience, Waseda University, Tokyo 169-8555 (Japan)
Description
This study examined the optical properties of an oxidized form of maghemite (γ-Fe2O3) nanoparticles and their protective effects against the photoaging of human skin fibroblasts irradiated with ultraviolet (UV) light. Nanoparticles with diameters ranging from 8.7 to 12 nm were prepared using a chemical co-precipitation method. The nanoparticles were coated with two surfactants to obtain a water-based product. The onset of the absorption of the γ-Fe2O3 nanoparticles in the UV-visible absorption spectra increased with increasing particle size. The γ-Fe2O3 nanoparticles significantly inhibited the production of matrix metalloproteinase-1 in human skin fibroblast HS 68 cells by 60% compared with the UV-irradiated control. These results suggest that γ-Fe2O3 nanoparticles have photoprotective properties, and have potential use as an agent against photoaging
Additional details
Identifiers
- DOI
- 10.1088/0957-4484/18/46/465201;
- PII
- S0957-4484(07)55502-9;
Publishing Information
- Journal Title
- Nanotechnology (Print)
- Journal Volume
- 18
- Journal Issue
- 46
- Journal Page Range
- p. 465201
- ISSN
- 0957-4484
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 39040380
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
- Descriptors DEI
- ABSORPTION; ABSORPTION SPECTRA; COPRECIPITATION; FIBROBLASTS; HUMAN POPULATIONS; IRON OXIDES; NANOSTRUCTURES; OPTICAL PROPERTIES; PARTICLE SIZE; PARTICLES; SKIN; SURFACTANTS; ULTRAVIOLET RADIATION
- Descriptors DEC
- ANIMAL CELLS; BODY; CHALCOGENIDES; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IRON COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PHYSICAL PROPERTIES; POPULATIONS; PRECIPITATION; RADIATIONS; SEPARATION PROCESSES; SIZE; SOMATIC CELLS; SORPTION; SPECTRA; TRANSITION ELEMENT COMPOUNDS