Efficacy of the application of the vascular stromal fraction derived of autologous adipose tissue in patients affected with radio-induced lesions

In the Burned Hospital of the City of Buenos Aires, an interdisciplinary Radiological Committee was created within the framework of a cooperation agreement with the Nuclear Regulatory Authority (ARN) for the diagnosis and treatment of radiation-induced cutaneous lesions, in accidental cases and medical overexposure. Within this patient population, those with grade 3-4 radiotoxicities according to the staging of the Radiation Therapy Oncology Group (RTOG) are frequently associated with unfavorable prognoses, work disability, lower quality of life and high costs of treatment for public health. At present, many of the chronic patients present improvements of irregular evolution, in spite of the current treatments, persisting with symptomatology and presenting recurrences. In this context, the development of new therapies that promote the healing of this type of wounds is of great importance. The Stromal Vascular Fraction (SVF) consisting of a heterogeneous population (endothelial cells, pericytes, fibroblasts, adult mesenchymal stem cells, among others) represents a new alternative in the field of regenerative medicine and tissue engineering, given its ability to favor Repair injuries, mitigate inflammation and sepsis. The stem cells derived from adipose tissue present in the SVF, unlike most stem cell-based procedures, do not require culture or previous expansion and are applied through minimally invasive interventions. In addition, treatment based on SVF has an additional advantage since it is an 'point of care' (PoC) type of autologous therapy or what is commonly referred to as point-of-care implementation therapies, by allowing for the extraction, purification and application the patient in a single procedure. The objective of this work is to evaluate the effectiveness of the therapy based on the autologous application of the SVF in the treatment of radiation-induced lesions, by monitoring the evolution of the wounds and the leukocyte infiltration indicators. (authors)