Published May 2020
| Version v1
Journal article
Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell
Creators
- 1. I. N. Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology, Federal Service for Supervision of Consumer Rights Protection and Human Welfare (Russian Federation)
- 2. N. I. Lobachevsky Nizhny Novgorod National Research State University (Russian Federation)
- 3. R. E. Alekseev Nizhny Novgorod State Technical University (Russian Federation)
- 4. Ministry of Health of the Russian Federation (Sechenov University). I. M. Sechenov First Moscow State Medical University (Russian Federation)
Description
We studied changes in the transcription of genes encoding cytokines (TNF, IL-6, IL-10, and IL-32), cell activation markers (ICAM1, CD38, Fas, and FCGRIII), ROS production catalyst (NOX2), autophagy (Beclin 1, LC3B, and p62) and apoptosis (BAX, BCL2) regulators in peripheral blood mononuclear cells upon contact with quantum dots CdSe/ZnS-MPA and CdSe/CdSeZnS/ZnS-PTVP. Up-regulation of TNF, ICAM1, Fas, p62 mRNA and down-regulation of the FCGRIII and NOX2 mRNA in response to the presence of quantum dots were revealed. The formation of serum protein corona on the surface of quantum dots abolished this effect.
Additional details
Identifiers
Publishing Information
- Journal Title
- Bulletin of Experimental Biology and Medicine
- Journal Volume
- 169
- Journal Issue
- 1
- Journal Page Range
- p. 95-99
- ISSN
- 0007-4888
- CODEN
- BEXBAN
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55061226
- Subject category
- S60: APPLIED LIFE SCIENCES; S77: NANOSCIENCE AND NANOTECHNOLOGY;
- Descriptors DEI
- APOPTOSIS; BIOLOGICAL MARKERS; BLOOD; BLOOD SERUM; BORON CHLORIDES; CADMIUM SULFIDES; CATALYSTS; GENES; GTP-ASES; LYMPHOKINES; MESSENGER-RNA; QUANTUM DOTS; TRANSCRIPTION; TRANSCRIPTION FACTORS; ZINC SELENIDES
- Descriptors DEC
- ACID ANHYDRASES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; BORON COMPOUNDS; BORON HALIDES; CADMIUM COMPOUNDS; CHALCOGENIDES; CHLORIDES; CHLORINE COMPOUNDS; ENZYMES; GROWTH FACTORS; HALIDES; HALOGEN COMPOUNDS; HYDROLASES; INORGANIC PHOSPHORS; MATERIALS; MITOGENS; NANOSTRUCTURES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHOSPHORS; PROTEINS; RNA; SELENIDES; SELENIUM COMPOUNDS; SULFIDES; SULFUR COMPOUNDS; ZINC COMPOUNDS
Optional Information
- Copyright
- Copyright (c) 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020