PET/CT finding in Castleman's disease

Castleman's disease, also known as angiofollicular lymph node hyperplasia, is a rare and poorly understood disease. This disease is a benign lymphoproliferative disorder and but can progress to lymphoma. Thus accurate diagnosis and treatment is very important. In this report, we present a case of multicentric Castleman's disease. We retrospectively reviewed a case (40 year-old male) that was histologically confirmed to Castleman's disease and was performed PET/CT. And from the PET/CT images before and after chemotherapy, peak standard uptake values and sites of abnormal FDG accumulations were recorded. The histological result was a plasma cell variant of Castleman's disease in both inguinal lymph nodes. PET/CT image showed FDG accumulations in both inguinal areas. And other FDG accumulations were noted in bilateral axillary and iliac regions. He received systemic chemotherapy of 6 cycles. In one month after last chemotherapy, PET/CT image was again performed. Previously noted FDG accumulations in bilateral axillary, iliac, and inguinal regions are seen with diminished intensity. Our result shows decreased intensity of abnormal FDG accumulations after systemic chemotherapy in Castleman's disease. In conclusion, PET/CT can useful for assessment of therapeutic effect in Castleman's disease