Published January 1997 | Version v1
Journal article Metadata-only

Validation of the limulus amebocyte lysate (LAL) test for routine PET radiopharmaceuticals

Creators

  • 1. Universitatsklinik der Ruhr-Universitat, Bad Oeynhausen (Germany). Herz-und Diabeteszentrum Nordrhein-Westfalen

Description

The kinetic turbidimetric limulus amebocyte lysate test was validated as a method for detecting endotoxins in short-lived radiopharmaceutical samples. Using this method, radiopharmaceuticals can be released for administration to humans after the test, without extensive loss of radioactivity. Inhibition or enhancement on the LAL results by the product samples were examined in more detail and eliminated. (Author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
48
Journal Issue
1
Journal Page Range
p. 51-54.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
28025641
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACETATES; AMMONIA; BIOASSAY; CARBON 11; ENDOTOXINS; FLUORINE 18; FLUORODEOXYGLUCOSE; IN VIVO; NITROGEN 13; POSITRON COMPUTED TOMOGRAPHY; QUALITY CONTROL; RADIOPHARMACEUTICALS; TOXICITY; VALIDATION
Descriptors DEC
ANTIGENS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACID SALTS; COMPUTERIZED TOMOGRAPHY; CONTROL; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDRIDES; HYDROGEN COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NANOSEC LIVING RADIOISOTOPES; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; PERFORMANCE TESTING; RADIOACTIVE MATERIALS; RADIOISOTOPES; TESTING; TOMOGRAPHY; TOXINS