Published September 2005 | Version v1
Journal article Metadata-only

The redox damage of lung and blood in rats inhaled radon and its progeny

Creators

  • 1. Suzhou Univ., Suzhou (China). The Radiation and Public Health College

Description

Objective: To study the redox damage of lung and blood cells in rats inhaled radon and its progeny. Methods: Male Wistar rats were exposed to radon and its progeny with the cumulative dose up to 27, 52, 105 working level month (WLM) respectively. The level of SOD (superoxide dismutase) and MDA (malondialdehyde) in blood, BALF and lung tissue were investigated. The change of intracellular ROS content in BALF (Bronchoalveolar lavage fluid) cell and PBMC (Peripheral blood mononuclear cell) were also investigated. Result: The level of SOD in blood and lung tissues significantly decreased and the level of MDA increased. The content of intracellular ROS in BALF cell and PBMC also increased remarkably. Conclusion: The inhalation of radon and its progeny can lead to the persistent disturbance of the redox state in rats. (authors)

Additional details

Publishing Information

Journal Title
Suzhou University Journal of Medical Science
Journal Volume
25
Journal Issue
5
Journal Page Range
p. 765-767
ISSN
1673-0399

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
37103631
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ALDEHYDES; BLOOD CELLS; COMPARATIVE EVALUATIONS; CONCENTRATION RATIO; DAUGHTER PRODUCTS; INHALATION; LUNGS; MALES; MONOCYTES; OXYGEN; RADIATION DOSES; RADIATION INJURIES; RADICALS; RADON; RATS; SUPEROXIDE DISMUTASE
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DIMENSIONLESS NUMBERS; DISEASES; DOSES; ELEMENTS; ENZYMES; EVALUATION; FLUIDS; GASES; INJURIES; INTAKE; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; NONMETALS; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PROTEINS; RADIATION EFFECTS; RARE GASES; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES

Optional Information

Notes
2 tabs., 8 refs.