Comparative studies on the immunostimulation by whole-body irradiation or vincristine sulphate
Creators
- 1. Universitaet des Saarlandes, Homburg/Saar (Germany, F.R.). Innere Medizin 1
- 2. Universitaet des Saarlandes, Homburg/Saar (Germany, F.R.). Radiologische Klinik
Description
Comparative experimentations were performed on Sprague-Dawley rats in order to study the immunostimulation by whole-body irradiation with 60Co gamma radiation (doses between 0.5 and 2 Gy) or application of vincristine sulphate (doses between 1.5 and 6 μg per 100 g body weight). The primary production of antibodies against erythrocytes of sheep was determined as immunity parameter. An immunostimulation was observed in all experiments. The irradiated groups showed the highest stimulation after 1 Gy, and the most stimulating dose of vincristine was 6 μg/100 g body weight. The radiogenic stimulation was more significant. As a reason for these stimulations, the authors suppose the different sensitivity of individual lymphocyte populations participating in the induction of the humoral immune response which leads to a relatively greater inactivation of T suppressor lymphocytes. (orig.)
Abstract (German)
An Sprague-Dawley-Ratten wurden vergleichende Untersuchungen zur Immunstimulation durch Ganzkoerperbestrahlung mit 60Co-Gammastrahlen (Dosen zwischen 0,5 und 2 Gy) oder durch Applikation von Vincristinsulfat (Dosen zwischen 1,5 und 6 μg pro 100 g Koerpergewicht) durchgefuehrt. Als Immunparameter wurde die primaere Antikoerperproduktion gegen Schaferythrozyten bestimmt. Eine Immunstimulation wurde in allen Experimenten beobachtet; fuer die bestrahlten Kollektive ergab sich die hoechste Stimulation nach 1 Gy; die maximal stimulierende Vincristindosis betrug 6 μg pro 100 g Koerpergewicht. Die radiogene Stimulation war ausgepraegter. Die Ursache fuer diese Stimulation wird vor allem in der differenten Sensibilitaet einzelner an der Induktion der humoralen Immunantwort beteiligten Lymphozytenpopulationen im Sinne einer relativ staerkeren Inaktivierung der T-suppressorlymphozyten angenommen. (orig.)Additional details
Additional titles
- Original title (German)
- Vergleichende Untersuchungen ueber die Immunstimulation durch Ganzkoerperbestrahlung oder Vincristinsulfat
Publishing Information
- Journal Title
- Strahlentherapie
- Journal Volume
- 159
- Journal Issue
- 10
- Series
- CODEN: STRAA.;Strahlentherapie.
- Journal Page Range
- 629-632
- ISSN
- 0039-2073
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 15027769
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANTIBODY FORMATION; COMPARATIVE EVALUATIONS; DRUGS; GAMMA RADIATION; GAMMA SOURCES; HEMOLYSINS; IMMUNE REACTIONS; LETHAL RADIATION DOSE; LYMPHOCYTES; PLANNING; RATS; STIMULATION; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; MAMMALS; MATERIALS; RADIATION DOSES; RADIATION SOURCES; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES