Published August 1987
| Version v1
Journal article
Study on the radiosensitization of AT1727 on human lung adenocarcinoma cell line SPC-A-1
- 1. Fudan Univ., Shanghai (China)
Description
Bimolane (AT1727), a new antitumour drug, was synthesized in China. Of late years, attention has been paid to the radiosensitizing activity of AT1727. In present study, this effect has been studied with hypoxic human lung adeno-carcinoma SPC-A-1 using colony formation assay in vitro. The results obtained showed that the SER(Sensitivity Enhancement Ratio) was 1.33 when the concentration of AT1727 was 0.15 m mol/L. Basing on the analysis of some results including those of solid tumour of mice, it is reasonable that AT1727 has radiosensitizing effect on hypoxic tumour cells
Additional details
Publishing Information
- Journal Title
- J. Radiat. Res. Radiat. Process.
- Journal Volume
- 5
- Journal Issue
- 3
- Series
- J. Radiat. Res. Radiat. Process.
- Journal Page Range
- 58-62
- ISSN
- 1000-3436
- CODEN
- FYYXE
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 19087999
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CELL CULTURES; IN VITRO; LUNGS; PATIENTS; RADIOSENSITIVITY; RADIOTHERAPY; SENSITIZERS; TUMOR CELLS; X RADIATION
- Descriptors DEC
- ANIMAL CELLS; BODY; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MEDICINE; ORGANS; RADIATIONS; REAGENTS; RESPIRATORY SYSTEM; THERAPY