Separations and synthesis support of pharmacokinetic studies

The research direction taken by ORNL in the OHER Complex Chemical Mixtures Program relies upon radiolabeled and unlabeled model compounds and well-characterized complex mixtures. Current research supported by the separations and synthesis activities of this project includes pharmacokinetic studies in skin and tracheal epithelium. Characterization of bioavailability, uptake, distribution, and metabolism are being conducted. To increase the discrimination of the measurements, a growing emphasis is being placed on the development of improved separations methods, ultimately for the isolation and determination of individual metabolites and also DNA adducts. This paper describes progress in these areas in the past year