Published November 2019 | Version v1
Journal article Metadata-only

Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum

Creators

  • 1. BioMark/ISEP, Instituto Superior de Engenharia Do Porto, Porto (Portugal)
  • 2. Centro de Investigação Em Química da Universidade Do Porto, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade Do Porto, Porto (Portugal)

Description

Highlights: • MIP@AuSPE biosensor for fast CA-125 detection in point-of-care. • Comparison between electrochemical and optical (SPR) sensor. • MIP sensor for a low detection limit of biomolecules with high molecular weight. • Determination of CA-125 in serum at clinically relevant levels (LOD = 0.1 U/mL). -- Abstract: Considering the high incidence level and mortality rate of ovarian cancer, particularly among the European female population, the carbohydrate antigen 125 (CA-125) was selected as the protein target for this study for the development of a MIP-based biosensor.

Additional details

Identifiers

DOI
10.1016/j.aca.2019.07.050;
PII
S0003267019308724;

Publishing Information

Journal Title
Analytica Chimica Acta
Journal Volume
1082
Journal Page Range
p. 126-135
ISSN
0003-2670
CODEN
ACACAM

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55021506
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ANTIGENS; CARBOHYDRATES; COMPARATIVE EVALUATIONS; DETECTION; ELECTROCHEMISTRY; FEMALES; MOLECULAR WEIGHT; MORTALITY; NEOPLASMS; POLYMERS; PROTEINS; SENSITIVITY; SENSORS
Descriptors DEC
CHEMISTRY; DISEASES; EVALUATION; ORGANIC COMPOUNDS

Optional Information

Copyright
Copyright (c) 2019 Elsevier B.V. All rights reserved.