Evaluation of radioprotective KMRC011 ¹⁸F-FDG PET

Radiation therapy is widely used in cancer treatment to kill the malignant cells. This principle of method was using the ionizing radiation which has high energy component such as alpha, beta or gamma ray. As this compound has emitted the high energy, radiation therapy occurs not only treated the malignant cell but also killed the normal tissue. Therefore, the protective agent for radio therapy has necessary for the patient who has treated radiation therapy. Absorbed high energy of ionizing radiation occur the harmful effect in living cell or organ in body. For this reason, we evaluate the ionizing radiation of ⁶⁰Co-radiation with or without KMRC011 using the ¹⁸F-FDG PET quantification analysis. In this study, we performed the three-difference group which is control, IR without KMRC011, IR with KMRC011. To evaluated effect of KMRC011, compared the percent change of SUV. Consequently, brain and bone marrow was decrease the percent change of SUV uptake similar to control group and it meant that KMRC011 has protect the radiation exposure. Therefore, this result may help to protect of irradiation in normal organ. In this study, we performed the three-difference group which is control, IR without KMRC011, IR with KMRC011. To evaluated effect of KMRC011, compared the percent change of SUV. Consequently, brain and bone marrow was decrease the percent change of SUV uptake similar to control group and it meant that KMRC011 has protect the radiation exposure.