Action mechanisms of antineoplastics of new synthesis and their possible use in therapy combined with radiation

In this work is described one research line of the Molecular Biology Laboratory of the Biology Department of the Instituto Nacional de Investigaciones Nucleares (ININ), in which microorganisms or human cells cultivations are used as model to study the effect of a compounds group of new synthesis that it will be use in the treatment against the cancer, as well as the possible synergism of these pharmaceuticals with the ionizing radiation. The results show that, without to reach discarding other cellular structures, an important target for these substances in the DNA, and to this respect other hypothesis are exposed to explain some possible mechanisms of its action. Also, the preliminary data are presented as for the additive effect with the gamma radiation of two of the compounds that are candidates for their next clinical application. This research is part of a project in collaboration with the Chemistry Faculty of the UNAM. (Author)