Effects of 60Co γ-rays irradiation on AT cell cycle progression
Creators
- 1. Suzhou Univ., Suzhou (China). School of Radiation Medicine and Public Health
Description
Objective: To explore the relationship between cell cycle progression and high radiosensitivity at AT5BIVA cells. Methods: Using flow cytometry to determine cell cycle distribution of AT5BIVA and GM0639 cells from 0-24 h after exposure to 2 Gy 60Co γ-rays and at the 24th hour after exposure to 0-6 Gy 60Co γ-rays. Results: After GM0639 cells were exposed to 2 Gy 60Co γ-rays, the percentage of G2/M cell increased with prolonged time. The percentage of G2/M cell augmented with irradiated dose at the 24th h in GM0639 cells exposed to 0-6 Gy 60Co γ-rays. The percentage of G2/M cells decreased with prolonged time and irradiated dose from 0-24 hour after AT5BIVA cells were exposed to 2 Gy 60Co γ-rays and at the 24th hour after AT5BIVA cells were exposed to 0-6 Gy 60Co γ-rays. Conclusion: The loss of cell cycle check points and the disfunction of DNA repair caused by ATM gene mutation may be responsible for high radiosensitivity of AT5BIVA cells. (author)
Additional details
Publishing Information
- Journal Title
- Acta Academiae Medicinae Suzhou
- Journal Volume
- 24
- Journal Issue
- 5
- Journal Page Range
- p. 592-594
- ISSN
- 1000-5749
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36107639
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CELL CYCLE; COBALT 60; DOSE-RESPONSE RELATIONSHIPS; FIBROBLASTS; GAMMA RADIATION; GENE MUTATIONS; RADIATION DOSES; RADIOSENSITIVITY; TELANGIECTASIS; TIME DEPENDENCE
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOVASCULAR DISEASES; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; MUTATIONS; NUCLEI; ODD-ODD NUCLEI; RADIATIONS; RADIOISOTOPES; SKIN DISEASES; SOMATIC CELLS; VASCULAR DISEASES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 4 tabs., 9 refs.