Could caffeine have some vaso protective effect?

Coffee is the most consumed hot drink in the world. it is part of the current and cultural diet of our society. There is a myth around coffee, considering it injurious based on clinical studies, whose results have been contradictory and without a solid scientific support. Nevertheless, in the last few years, there have been studies that describe the kindness of the coffee upon convecting, digestive and cardiovascular system. We want to present the vasodilator effect of caffeine in a experimental model that used aorta rings of normal and hipercholesterolemic rabbits, mounted in a organ bath system (Kent scientific corporation, Litchfield CT containing krebs, solution. The solution was kept at 37 Celsius degrade and aerated continuously with a 95% o2 5% CO2 gas mixture. The rings were pre contracted with norepinephrine (-5.5 log m) and relaxed with nitroglycerin (endothelium independent relaxation), acetylcholine (endothelium dependant relaxation) and caffeine