Bioresorbable polymer matrices impregnated with BMP-2

Bioresorbable matrices from poly(lactic-co-glycolic acid) containing therapeutically significant concentrations of bone morphogenetic protein 2 (BMP-2) was formed by super-critical fluid encapsulation and surface-selective laser sintering. Biocompatibility of these matrices and the kinetics of BMP-2 release from their volume into physiological saline was investigated. It was shown experimentally that the release of BMP-2 was almost uniform for 15 days. The subsequent use of laser sintering contributed to a longer retention of BMP-2. High cytocompatibility of the obtained matrices with cultures of mesenchymal stem cells was shown in vitro. (paper)