Preparation and biodistribution of mixed complexes of 99Tcm-phosphine

To explore the synthetic methods of phosphine mixed complexes of technetium-99m and look for new heart imaging agents, one N3S ligand (MVNE) and three phosphine ligands were synthesized. 99Tcm-MVNE prepared at room temperature through ligand-exchange reaction reacts with the three phosphine ligands respectively to obtain three mixed complexes of 99Tcm-MVNE-phosphine. The biodistribution studies in mice indicate that these complexes exhibit pretty high myocardial uptake and high blood clearance rate