Architectures Based on Gold NPs Associated with Targeting Agents for Tumour Therapy by Photothermia

In the framework of the CRP programme, France has worked in collaboration with Italy and Japan on the development of new gold NP architecture for tumour ablation using photothermia. The main condition for such applications is that NPs exhibit an SPR in the NIR region. The CEA has a γ ray irradiation facility and EB accelerator for radiation grafting of polymers. In this programme, gold NPs were synthesized in plain, hollow and core shell forms. The plain gold NPs were covered with PVDF by nanoemulsion polymerization to prepare particles for further radiografting. The cytotoxicities of the HGNPs absorbing in the NIR region were evaluated. As these NPs were promising materials, photothermal effects on tumour cells have been examined. (author)