A study of the radioprotective power of imidazole, benzimidazole and naphazoline on mice placed in a pure oxygen atmosphere
Description
The authors exposed mice, males and females, to gamma rays from cobalt 60. They established the LD/100/30 (1050 R) and tested three radioprotective drugs: Imidazole, Benzimidazole and Naphazoline just as they experimented with X rays. The effectiveness is respectively for females: 65 per cent, 70 per cent and 90 per cent, for males 25 per cent, 55 per cent and 100 per cent. The three substances then have been tested with animals placed in a pure oxygen atmosphere with increasing pressures from 1.1 to 2.5 atmospheres. The radioprotective power of Imidazole and Benzimidazole is strongly decreased whereas Naphazoline conserves its properties. In this case the effectiveness of this drug may be compared to cysteamine efficacy used as a reference in this work. (authors)
Abstract (French)
Par exposition de souris C3H/He/Orl des deux sexes au rayonnement gamma du 60Co, les auteurs, apres avoir determine la dose letale (1050 R), ont teste trois substances radioprotectrices: l'Imidazole, le Benzimidazole et la Naphazoline comme ils l'avaient deja fait pour des rayons X. Rapportee a la dose letale, l'efficacite de ces composes chimiques est respectivement, en ce qui concerne les femelles, de 65 pour cent, 70 pour cent et 90 pour cent, tandis qu'elle est de 25 pour cent, 55 pour cent et 100 pour cent pour les males. Ces trois substances ont ete ensuite experimentees sur des animaux places dans une atmosphere d'oxygene pur a des pressions allant de 1,1 a 2,5 atmospheres. Si pour l'Imidazole et le Benzimidazole les proprietes radioprotectrices sont considerablement diminuees, celles de la Naphazoline ne sont pratiquement pas modifiees. Pour cette substance l'efficacite est donc dans ces conditions sensiblement equivalente a celle de la cysteamine qui a servi de reference pour cette experimentation. (auteurs)Files
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Additional details
Additional titles
- Original title (French)
- Etude du pouvoir radioprotecteur de l'imidazole, du benzimidazole et de la naphazoline sur des souris placees dans une atmosphere d'oxygene pur
Publishing Information
- Imprint Pagination
- 36 p.
- Report number
- CEA-R--4110
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 54027884
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACUTE IRRADIATION; BENZIMIDAZOLES; CONTROLLED ATMOSPHERES; CYSTEAMINE; EFFICIENCY; EXPOSURE CHAMBERS; GAMMA RADIATION; INTRAPERITONEAL INJECTION; LETHAL IRRADIATION; MICE; MORTALITY; OXYGEN; PRESSURE DEPENDENCE; RADIOSENSITIVITY; SEX DEPENDENCE; SURVIVAL CURVES; TOXICITY
- Descriptors DEC
- ACUTE EXPOSURE; AMINES; ANIMALS; ATMOSPHERES; AZOLES; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INJECTION; INTAKE; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SENSITIVITY; THIOLS; VERTEBRATES
Optional Information
- Notes
- 12 refs.; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses