State of hemostatic homeostasis in patients with rheumatoid arthritis in the course of multimodality therapy including radiosynovectomy

Platelet functional activity, plasma coagulation and fibrinolysis were studied in patients with rhematoid arthritis (RA) against a background of various therapeutic modalities. Therapy with non-steroid anti-inflammatory agents resulted in an increase in platelet and plasma coagulating activity and inhibition of fibrinolysis. An insignificant rise of desaggregation of platelet aggregates was noted 2 weeks after intraarticular administration of 198Au against a background of therapy with nonsteroid anti-inflammatory agents. Mydocalm incorporated in a dose of 1-2 mg/kg in the therapeutic scheme did not change significantly blood coagulation indices