Protective effects of chelating agents of catechols amino carboxylic acid type on radiation injury induced by radiothorium in mice II. delayed administration
- 1. Fudan Univ., Shanghai (China). Inst. of Radiation Medicine
Description
Objective: To explore antioxidation efficacy of chelating agents (9501, 7601) of catechols amino carboxylic acid type for radiothorium in vivo and relationship between their antioxidation and decorporation effects. To verify whether 9501 and 7601 could improve the protective effects for internal radiation injury. Methods: The chelating agents were administered intramuscularly to ICR mice 3 days after intraperitoneal injection of 0.6 MBq 234Th-citrate for three consecutive days and the animals were sacrificed eight days later. The 234Th radioactivity in the whole body and its retention in the liver and skeleton were determined. The malondialdehyde (MDA) production as an index of 234Th-induced lipid peroxidation in bone marrow and liver was assayed and the numbers of bone marrow nucleated cells (NBMNC) were counted. The pathological changes of bone marrow and liver tissue were observed. Results: When 9501 and 7601 and DTPA were postponed to administer to 234Th-incorporated mice, the whole body radioactivity was only decreased by 15%-16% and the retention of 234Th in the liver, and skeleton was reduced to 77%-79% and 72%-75% as compared with the control group, respectively. They showed the similar removal effectiveness which was significantly lower than that when administered promptly. However, 9501 and 7601 could inhibit 234Th-induced lipid peroxidation, causing significant reduction of MDA content in bone marrow and liver, and markedly ameliorate histopathological changes of bone marrow and liver tissue in 234Th-treated mice. DTPA appeared to have a lower effectiveness. VitE hadn't decorporation activity and slightly alleviated internal radiation injury. Conclusion: The chelating agents 9501 and 7601 of catechols amino carboxylic acid type have double functions of more effective decorporation and antioxidation and can improve the curative effects. They are worth further investigation
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 23
- Journal Issue
- 6
- Journal Page Range
- p. 426-430
- ISSN
- 0254-5098
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35093028
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AMINO ACIDS; BONE MARROW; CARBOXYLIC ACIDS; CHELATING AGENTS; CONTAMINATION; DECONTAMINATION; INTERNAL IRRADIATION; LIPIDS; LIVER; MICE; PEROXIDES; PYROCATECHOL; RADIATION INJURIES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; RETENTION; THORIUM 234
- Descriptors DEC
- ACTINIDE NUCLEI; ANIMAL TISSUES; ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBOXYLIC ACIDS; CLEANING; DAYS LIVING RADIOISOTOPES; DEVELOPERS; DIGESTIVE SYSTEM; DISEASES; DRUGS; EVEN-EVEN NUCLEI; GLANDS; HEAVY NUCLEI; HEMATOPOIETIC SYSTEM; HYDROXY COMPOUNDS; INJURIES; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHENOLS; POLYPHENOLS; RADIATION EFFECTS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; THORIUM ISOTOPES; VERTEBRATES