Published 1979 | Version v1
Book Metadata-only

Comparison of the rat and mouse model for monitoring the radiochemical purity of Tc-99m human serum albumin

Creators

  • 1. Radiation Protection Bureau, Ottawa, Ontario

Description

Kits from 4 manufacturers were reconstituted according to package insert instructions. The radiochemical purity of each preparation was assessed by in vitro techniques prior to biological distribution studies in rats and mice. Tissues of interest were blood and liver. Analysis of variance (at p = 0.05) indicated that there was a significant difference between the tissue distribution results for rats and mice. Also, there was a significant difference between preparations based on the blood results for either rats or mice but not the liver results. Only the blood results reflected the in vitro test values

Additional details

Publishing Information

Publisher
Society of Nuclear Medicine, Inc.
Imprint Place
New York, NY
Imprint Title
Radiopharmaceuticals. II
Journal Page Range
p. 25-31.

Conference

Title
2. international symposium on radiopharmaceuticals.
Dates
18 - 23 Mar 1979.
Place
Seattle, WA, USA.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
12592036
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ALBUMINS; BIOLOGICAL LOCALIZATION; BLOOD; COMPARATIVE EVALUATIONS; DISTRIBUTION; IMPURITIES; ISOMERIC NUCLEI; LIVER; MICE; RADIOMETRIC ANALYSIS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; TECHNETIUM 99; TISSUES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CHEMICAL ANALYSIS; DIGESTIVE SYSTEM; DRUGS; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES