Published August 1995 | Version v1
Journal article Metadata-only

Labeling McAb 3H11 and its Fab fragment with 211At and their immuno-reactivities and injury effects on human gastric cancer cells

Creators

  • 1. Sichuan Union University, Chengdu, SC (China). Inst. of Nuclear Science and Technology

Description

At antigastric cancer monoclonal antibody, 3H11, and its Fab fragment, were labeled using p-(211At)-astatobenzoic acid (pAtBA) intermediate, in the yields of more than 30%. The results of in vitro experiments show that 211At-3H11 and 211At-3H11 Fab are stable, and have specific immuno-reactivities and cytotoxic effects to human gastric cancer cell M85. The cytotoxic effects are dependent on the concentration of 211At-3H11 or 211At-3H11 Fab and obviously stronger than that of Na211At

Additional details

Publishing Information

Journal Title
Nuclear Science and Techniques
Journal Volume
6
Journal Issue
3
Journal Page Range
p. 154-158.
ISSN
1001-8042
CODEN
NSETEC

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
27005540
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ASTATINE 211; CARCINOMAS; CONCENTRATION RATIO; IMMUNE REACTIONS; IN VITRO; LABELLED COMPOUNDS; LABELLING; MAN; MONOCLONAL ANTIBODIES; RADIATION INJURIES; RADIOIMMUNOTHERAPY; STABILITY; STOMACH
Descriptors DEC
ALPHA DECAY RADIOISOTOPES; ANIMALS; ANTIBODIES; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOTHERAPY; INJURIES; ISOTOPES; MAMMALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIATION EFFECTS; RADIOISOTOPES; RADIOTHERAPY; THERAPY; VERTEBRATES