Published 1985 | Version v1
Journal article Metadata-only

A whole-body autoradiographic study on the distribution of tritium in cynomolgus monkeys dosed with a tritiated extract of Ruscus

Creators

  • 1. Ecole Nationale Veterinaire, 31 - Toulouse (France). Laboratoire de Radioelements et d'Etudes Metaboliques (INRA)
  • 2. Centre de Recherches Pierre Fabre, 81 - Castres (France)

Description

A metabolic study has been performed on macaca monkey treated with a tritiated Ruscus extract. There is a rather good absorption of radioactivity when the preparation is delivered orally. The percutaneous absorption is much lower. A large part of the delivered activity is excreted in feces and urine. Sapogenins are the main urinary metabolites. In the body, tritium is mainly localized in the liver, the kidney, the spleen (white pulp) and the bone marrow

Abstract (French)

L'etude de la distribution d'un extrait de Ruscus tritie a ete realisee chez des singes macaques. L'absorption de la radioactivite est assez bonne pour la voie orale. L'absorption percutanee est plus faible, mais pertinente. La radioactivite est eliminee par voies fecale et urinaire. Dans l'urine, on retrouve surtout des sapogenines. Dans l'organisme, le tritium est mis en evidence dans le foie, le rein, la pulpe blanche de la rate et la moelle osseuse

Additional details

Additional titles

Original title (French)
Etude autoradiographique de la distribution du tritium chez des singes macaques traites par un extrait de Ruscus tritie

Publishing Information

Journal Title
Ann. Pharm. Fr.
Journal Volume
43
Journal Issue
6
Series
Ann. Pharm. Fr.
Journal Page Range
573-584
ISSN
0003-4509
CODEN
APFRA

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
17077589
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
AUTORADIOGRAPHY; BIOLOGICAL LOCALIZATION; DRUGS; MACACUS; METABOLISM; ORAL ADMINISTRATION; TRACER TECHNIQUES; TRITIUM COMPOUNDS
Descriptors DEC
ANIMALS; HYDROGEN COMPOUNDS; INTAKE; ISOTOPE APPLICATIONS; MAMMALS; MONKEYS; PRIMATES; VERTEBRATES