Published February 1998
| Version v1
Journal article
Chromatin and DNA chain fragmentation studies on apoptosis in immune cells induced by 235U and radioprotection of IL-2 or IL-6
Description
The apoptosis in human acute lymphoblastic leukemia cell line Molt-4 cell and macrophage cell line Ana-1 cell are studied after internal irradiation with enriched uranium 235U. The cumulative absorption dose of 235U in cultural cells through different periods are estimated. The fluorescence microscopic observations indicate that Molt-4 and Ana-1 immune cells internally irradiated by 235U displayed significant chromatin fragmentation and marked pyknosis in immune cells nuclei, as well as DNA chain fragmentation and apoptotic bodies formation. It should be noted that DNA chain fragmentation induced by 235U may be inhibited statistically by IL-2 (interleukin-2) or IL-6 treatment
Additional details
Publishing Information
- Journal Title
- Nuclear Science and Techniques
- Journal Volume
- 9
- Journal Issue
- 1
- Journal Page Range
- p. 49-51.
- ISSN
- 1001-8042
- CODEN
- NSETEC
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29019063
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHROMATIN; DNA; ENRICHED URANIUM; FLUORESCENCE; INTERNAL IRRADIATION; LEUKEMIA; LYMPHOCYTES; MACROPHAGES; MAN; MICROSCOPY; RADIATION DOSES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; STRAND BREAKS; URANIUM 235
- Descriptors DEC
- ACTINIDE NUCLEI; ACTINIDES; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; DNA DAMAGES; DRUGS; ELEMENTS; EMISSION; EVEN-ODD NUCLEI; HEAVY NUCLEI; IMMUNE SYSTEM DISEASES; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPE ENRICHED MATERIALS; ISOTOPES; LEUKOCYTES; LUMINESCENCE; MAMMALS; MATERIALS; METALS; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHAGOCYTES; PHOTON EMISSION; PRIMATES; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; SOMATIC CELLS; SPONTANEOUS FISSION RADIOISOTOPES; URANIUM; URANIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES