Published March 1984 | Version v1
Journal article

Initial studies of hypoxic radioprotection by deoxygenated dextran-hemoglobin

  • 1. Univ. of Toronto, Ontario

Description

Initial studies were performed to examine the potential of perfused dextran-hemoglobin to protect pig skin or mouse bone marrow cells against radiation damage. Some protection was indicated in both systems. In the pig skin a protection factor of 1.5 was observed for moist desquamation, and 2.0 for necrosis. These results suggest the possibility of using blood substitutes to induce tissue hypoxia for therapeutic purposes

Additional details

Publishing Information

Journal Title
Int. J. Radiat. Oncol., Biol. Phys.
Journal Volume
10
Journal Issue
3
Series
Int. J. Radiat. Oncol., Biol. Phys.
Journal Page Range
369-373
ISSN
0360-3016