Published 1993
| Version v1
Book
Recovery of 213Bi from an 225Ac cow: Application to the radiolabeling of monoclonal antibodies with the alpha-emitter 213Bi
- 1. National Cancer Institute, Bethesda, MD (United States)
- 2. Institute for Transuranium Elements, Karlsruhe (Germany)
- 3. Alphamedical, Amsterdam (Netherlands)
Description
A column separation method was used to milk the α-emitting radionuclide, 213Bi, from an 225Ac cow: Milking was done on a 150 mm3 column of MP-50 cation exchange resin with the acids HI or HCl or both. To assay the complexation behavior of 213Bi, thin-layer chromatography was used with μM amounts of DTPA complexing ligand. Radiolabeling was done with the B3 monoclonal antibody (mAb) conjugate of the novel ligand CHX-B DTPA. The optimal results to-date are 38 μCi (76%) of 50 μCi213Bi incorporated into the mAb conjugate. The final specific activity was 0.24 μCi/μg. These results are discussed and some comparisons to the 212Bi system are made
Additional details
Publishing Information
- Publisher
- American Chemical Society.
- Imprint Place
- Washington, DC (United States)
- Imprint Title
- 206th ACS national meeting
- Imprint Pagination
- 1905 p.
- Journal Page Range
- p. 873, Paper NUCL 94.
Conference
- Title
- 206. American Chemical Society (ACS) national meeting.
- Dates
- 22-27 Aug 1993.
- Place
- Chicago, IL (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 26000244
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ACTINIUM 225; BISMUTH 212; BISMUTH 213; DTPA; HYDRIODIC ACID; HYDROCHLORIC ACID; ION EXCHANGE CHROMATOGRAPHY; LABELLING; MONOCLONAL ANTIBODIES; PRODUCTION; RADIOISOTOPE GENERATORS; RADIOPHARMACEUTICALS; THIN-LAYER CHROMATOGRAPHY
- Descriptors DEC
- ACTINIDE NUCLEI; ACTINIUM ISOTOPES; ALPHA DECAY RADIOISOTOPES; AMINO ACIDS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BISMUTH ISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CHLORINE COMPOUNDS; CHROMATOGRAPHY; DAYS LIVING RADIOISOTOPES; DRUGS; HALOGEN COMPOUNDS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; HYDROGEN COMPOUNDS; INORGANIC ACIDS; INORGANIC COMPOUNDS; IODINE COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES
Optional Information
- Secondary number(s)
- CONF-930802--.