Inhibition of natural killer cell activity by eicosapentaenoic acid in vivo and in vitro
- 1. Toyama Medical and Pharmaceutical Univ., Japan
Description
To examine the effects of in vivo eicosapentaenoic acid (EPA) on natural killer (NK) cell activity, C3H/He mice each received a single intraperitoneal bolus of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG). Spleen cells were tested for NK activity using 51Chromium-release assays against YAC-1 target cells. Forty eight hours after injection, NK activity was inhibited in a dose-dependent manner. EPA-TG emulsion also inhibited the NK activity of NK-enriched effector cells. Decreased cytotoxicity was first noted 24 hr after injection; it resumed the baseline by 7 days. The addition of EPA-TG emulsion to a cytotoxicity assay system resulted in moderate depression of NK activity. These results demonstrate that EPA has significant immunomodulatory effects on NK activity
Additional details
Publishing Information
- Journal Title
- Biochem. Biophys. Res. Commun.
- Journal Volume
- 150
- Journal Issue
- 1
- Series
- Biochem. Biophys. Res. Commun.
- Journal Page Range
- 497-505
- ISSN
- 0006-291X
- CODEN
- BBRCA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19050190
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOCHEMICAL REACTION KINETICS; CELL KILLING; CELL PROLIFERATION; CHROMIUM 51; DOSE-RESPONSE RELATIONSHIPS; EICOSANOIC ACID; EMULSIONS; IN VITRO; IN VIVO; INHIBITION; LYMPHOCYTES; MICE; MONOCYTES; SPLEEN CELLS; TRACER TECHNIQUES; TRIGLYCERIDES
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CHROMIUM ISOTOPES; COLLOIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISPERSIONS; ELECTRON CAPTURE RADIOISOTOPES; ESTERS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LEUKOCYTES; LIPIDS; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; REACTION KINETICS; RODENTS; SOMATIC CELLS; VERTEBRATES