Published 1990 | Version v1
Report Metadata-only

Malonic ester synthesis of various α-(11,14C-methyl)-carboxylic acids and related compounds

Creators

  • 1. Kitasato Univ., Sagamihara (Japan)

Description

In this paper, the authors continue the study of the malonic ester synthesis mainly of alpha-(11,14C-methyl)-carboxylic acids and their behavior in mice. Preparation of (2-11,14C-ethyl)-ketones is also delineated. This synthesis consists of three steps: methylation, hydrolysis, and decarboxylation. Various conditions in them were examined to find out suitable procedures for carbon-11 labelling. Labelled products were injected into mice and the organ distribution determined

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 426-428.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23029840
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
BRAIN; CARBON 11; CARBOXYLIC ACIDS; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; DICARBOXYLIC ACIDS; ESTERS; HYDROLYSIS; IN VIVO; LABELLED COMPOUNDS; LABELLING; METABOLISM; METHYL IODIDE; METHYLATION; MICE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CHEMICAL REACTIONS; DECOMPOSITION; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SOLVOLYSIS; SYNTHESIS; VERTEBRATES

Optional Information

Secondary number(s)
CONF-9006363--Absts.