Published March 2013 | Version v1
Journal article Metadata-only

Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

Creators

  • 1. Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi, Hyogo 673-8558 (Japan)
  • 2. Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586 (Japan)
  • 3. Section of Translational Research, Hyogo Cancer Center, Akashi, Hyogo 673-8558 (Japan)
  • 4. Division of Pediatrics, University of Miyazaki, Miyazaki, Miyazaki 889-1692 (Japan)
  • 5. Department of Pediatrics, Saiseikai Shiga Hospital, Ritto, Shiga 520-3046 (Japan)
  • 6. Department of Pathology, Hyogo Cancer Center, Akashi, Hyogo 673-8558 (Japan)
  • 7. Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017 (Japan)
  • 8. Department of Neurosurgery, Osaka Medical College, Takatuki, Osaka 569-8686 (Japan)
  • 9. Research Center for Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, Sakai, Osaka 599-8570 (Japan)
  • 10. Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun, Osaka 590-0494 (Japan)
  • 11. Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Sennan-gun, Osaka 590-0494 (Japan)

Description

Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono-L-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS. - Highlights: ► Human clear cell sarcoma (CCS)-bearing nude mice were used in this study. ► The human CCS in the nude mice disappeared after BNCT. ► The efficacy of BNCT for human CCS is demonstrated here for the first time

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2012.12.001

Additional details

Identifiers

DOI
10.1016/j.apradiso.2012.12.001;
PII
S0969-8043(12)00582-9;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
73
Journal Page Range
p. 96-100
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
45111104
Subject category
S07: ISOTOPES AND RADIATION SOURCES; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BORON; MICE; NEUTRON CAPTURE THERAPY; PHENYLALANINE; SARCOMAS; THERMAL NEUTRONS
Descriptors DEC
AMINO ACIDS; ANIMALS; AROMATICS; BARYONS; CARBOXYLIC ACIDS; DISEASES; ELEMENTARY PARTICLES; ELEMENTS; FERMIONS; HADRONS; MAMMALS; MEDICINE; NEOPLASMS; NEUTRON THERAPY; NEUTRONS; NUCLEAR MEDICINE; NUCLEONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOLOGY; RADIOTHERAPY; RODENTS; SEMIMETALS; THERAPY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.