The sequential production of [18F]-6-FDOPA and [18F]-F-m-TYROSINE (or [18F]-2-FDG) from the same dilute [18F]F2 target gas

The recovery of [18F] from the target is 65 ± 8% when 0.4% F2 in neon is the target gas. The fraction of [18F] trapped in the reaction vessel during direct fluorination of aromatic compounds is dependent upon the solvent used for the reaction. For the fluorination of L-DOPA in HF/BF3, the [18F] trapped in the reaction vessel is 36 ± 4% whereas in other solvents it is 60 ± 5%. The percent recovery of [18F] is even lower for less activated aromatic rings such as ortho, meta and para-tyrosine in HF/BF3 (12-16%). The aim of this work is to demonstrate how to utilize this unreacted, readily available, [18F]F2 for developmental work