Published 1984 | Version v1
Journal article Metadata-only

In vivo persistence of sister chromatid exchanges (SCE) induced by gamma rays in mouse bone marrow cells

Creators

  • 1. Instituto Nacional de Investigaciones Nucleares, Mexico City, Mexico

Description

The sister chromatid exchange (SCE) frequencies induced in bone marrow cells by in vivo irradiation with gamma rays before or after bromodeoxyuridine (BrdUrd) incorporation were compared. The frequency of SCE at different postirradiation times was also measured in bone marrow cells in vivo, irradiated before BrdUrd incorporation. Increased sensitivity to SCE induction by radiation was found in cells after BrdUrd incorporation for one cycle when compared with cells irradiated before BrdUrd incorporation. The increased SCE frequency persisted for at least 72 hr after the initial irradiation, implying that the gamma ray-induced lesion(s) capable of eliciting an SCE are persistent and cannot be easily repaired

Additional details

Publishing Information

Journal Title
Environ. Mutagen.
Journal Volume
6
Journal Issue
4
Series
Environ. Mutagen.
Journal Page Range
529-537

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
16030302
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL REPAIR; BONE MARROW CELLS; BUDR; GAMMA RADIATION; GENETIC RADIATION EFFECTS; IN VIVO; MICE; MUTATION FREQUENCY; RADIATION EFFECTS; SISTER CHROMATID EXCHANGES
Descriptors DEC
ANIMAL CELLS; ANIMALS; ANTIMETABOLITES; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BROMOURACILS; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; MAMMALS; MUTATIONS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATIONS; RIBOSIDES; RODENTS; SOMATIC CELLS; URACILS; VERTEBRATES