Synthesis of 13C- and 14C-labeled 3-(dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine

Synthesis of 3-(dichloroacetyl)-5-(2-fuanyl)-2,2-dimehtyloxazolidine (common name: furilazole) labeled with carbon-14 and carbon-13 are described. Two routes for the synthesis of labeled trimethylsilyl cyanide, a precursor to furilazole, are described. One method can be carried out on milligram scale and is suitable for a high specific activity preparation while the second method is suitable for preparation on gram scale. Carbon-14 labeled furilazole was obtained from isotopically labeled potassium cyanide in 5 steps with an overall yield of 28-34%. (author)