Published 1999 | Version v1
Miscellaneous Open

Application of 10B entrapped PEG-liposome to boron neutron-capture therapy for pancreatic cancer model in vivo

Creators

  • 1. Dept. of Surgery, Inst. of Medical Science, Tokyo Univ. (Japan)
  • 2. Dept. of Pharmaceutics, Teikyo Univ., Kanagawa (Japan)
  • 3. Coll. of Industrial Technology, Nihon Univ., Narashino, Chiba (Japan)
  • 4. Omiya Research Lab., Nikken Chemicals Co. Ltd., Saitama (Japan)
  • 5. Research Reactor Inst., Kyoto Univ., Kumatori, Osaka (Japan)
  • 6. Inst. Jozef Stefan, Ljubljana (Slovenia)
  • 7. Dept. of Epidemiology, School of Medicine, Juntendo Univ., Tokyo (Japan)
  • 8. Inst. for Atomic Reactor, Rikkyo Univ., Yokosuka, Kanagawa (Japan)

Description

The cytotoxic effects for tumor were evaluated with intravenous injection 10B PEG-liposome (Stealth liposome) on human pancreatic carcinoma wenografts in nude mice with thermal neutron irradiation. After thermal neutron irradiation of mice injected with 10B bare-liposome or 10B PEG liposome, AsPC-1 tumour growth was suppressed relative to controls. Injection of 10B PEG-liposome caused the greatest tumour suppression with thermal neutron irradiation in vivo. These results suggest that intravenous injection of 10B PEG-liposome can increase the retention of 10B atoms by tumor cells, causing tumor growth suppression in vivo upon thermal neutron irradiation.(author)

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Additional details

Publishing Information

Publisher
Nuclear Society of Slovenia
Imprint Place
Ljubljana (Slovenia)
ISBN
961-6207-13-X
Imprint Title
International Conference Nuclear Energy in Central Europe 99, V. 2. Proceedings. Embedded Meeting Neutron Imaging Methods to Detect Defects in Materials
Imprint Pagination
123 p.
Journal Page Range
p. 709-715
Report number
INIS-SI--02-003

Conference

Title
International Conference on Nuclear Energy in Central Europe 99
Dates
6-9 Sep 1999
Place
Portoroz (Slovenia)

INIS

Country of Publication
Slovenia
Country of Input or Organization
Slovenia
INIS RN
33071083
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AUTORADIOGRAPHY; LIPOSOMES; MICE; NEOPLASMS; NEUTRON CAPTURE THERAPY; NEUTRON RADIOGRAPHY; PANCREAS; RADIOTHERAPY
Descriptors DEC
ANIMALS; BODY; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; GLANDS; INDUSTRIAL RADIOGRAPHY; MAMMALS; MATERIALS TESTING; MEDICINE; NEUTRON THERAPY; NONDESTRUCTIVE TESTING; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RADIOTHERAPY; RODENTS; TESTING; THERAPY; VERTEBRATES

Optional Information

Notes
9 refs., 1 tab., 2 figs.