Published 1989
| Version v1
Report
Open
The theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and samarium-145 as a brachytherapy source
Creators
- 1. Ohio State Univ., Columbus, OH (USA)
- 2. Brookhaven National Lab., Upton, NY (USA)
Description
High grade astrocytomas have proven resistant to all conventional therapy. A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (IdUrd) and by stimulation of Auger electron cascades through absorption of low energy photons in iodine (Photon activation) is described. Clinical studies using IdUrd, 192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting samarium-145 for 192Ir in this protocol is expected to produce enhanced results. 15 refs
Availability note (English)
MF available from INIS under the Report Number; NTIS, PC A02/MF A01 as DE90011518; OSTI; INIS.Files
21094388.pdf
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Additional details
Publishing Information
- Imprint Pagination
- 8 p.
- Report number
- BNL--44560
Conference
- Title
- 10. meeting of the world society for stereotactic and functional neurosurgery.
- Dates
- 2-5 Oct 1989.
- Place
- Maebashi (Japan).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21094388
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ABSORPTION; AUGER EFFECT; BRAIN; DIAGNOSTIC TECHNIQUES; DNA; DOSIMETRY; DRUGS; EXTERNAL IRRADIATION; GLIOMAS; IODODEOXYURIDINE; IRIDIUM 192; NEOPLASMS; PHOTONS; RADIATION DOSES; RADIATION SOURCES; RADIOSENSITIVITY; RADIOTHERAPY; SAMARIUM 145; SENSITIZERS; THERAPY; TUMOR CELLS; USES
- Descriptors DEC
- ANIMAL CELLS; ANTIMETABOLITES; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BOSONS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTARY PARTICLES; EVEN-ODD NUCLEI; HEAVY NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODOURACILS; IRIDIUM ISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MASSLESS PARTICLES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIOISOTOPES; RARE EARTH NUCLEI; REAGENTS; RIBOSIDES; SAMARIUM ISOTOPES; URACILS; YEARS LIVING RADIOISOTOPES
Optional Information
- Contract/Grant/Project number
- Contract AC02-76CH00016
- Secondary number(s)
- CONF-8910409--1.