Published 1975 | Version v1
Report Metadata-only

Early kinetics of iodide and pertechnetate: establishment of a compartmental model from data obtained with a scintillation camera

Creators

  • 1. Brussels Univ. (Belgium)
  • 2. Hopital Universitaire Saint-Pierre, Brussels (Belgium)

Description

The early thyroid metabolism of iodide may be described by three parameters: the unidirectional clearance C (active iodide transport from the plasma to the thyroid cells), the leakage coefficient ksub(TB) (back-diffusion of thyroid iodide to the plasma) and the organification constant ksub(b) (bonding of iodide to the thyroid proteins). These three parameters were determined, together with their variation under the influence of competing anions such as perchlorate or antithyroid agents such as methyl mercapto imidazol (MMI). After intraveinous injection of the tracer dose (I-131 or Tc-99m) the heart and thyroid activities were measured continuously by external counting with a scintillation camera. The simplest model consistent with facts is a system with 7 compartments for iodide and 6 for pertechnetate. It allows the plasma concentration variation to be determined from the data obtained by external counting, parameters C, ksub(TB) and ksub(b), and MMi-induced organification inhibition

Abstract (French)

Le metabolisme thyroidien precoce de l'iodure peut etre decrit par trois parametres: la clearance unidirectionnelle C (transport actif de l'iodure du plasma vers les cellules thyroidiennes), le coefficient de fuite ksub(TB) (retrodiffusion d'iodure thyroidien vers le plasma), la constante d'organification ksub(b) (liaison de l'iodure aux proteines thyroidiennes). On a determine ces trois parametres, ainsi que leur variation sous l'influence d'anions competiteurs tels que le perchlorate, ou d'antithyroidiens tels que le Methyl Mercapto Imidazol (MMI). Apres injection intraveineuse de la dose traceuse (I-131 ou Tc-99m), on a realise la mesure continue des activites cardiaques et thyroidiennes par comptage externe a l'aide d'une camera a scintillation. Le modele le plus simple compatible avec les donnees est un systeme a 7 compartiments pour l'iodure et 6 pour le pertechnetate. Ce modele permet de determiner: l'evolution de la concentration plasmatique a partir des donnees obtenues par comptage externe, les parametres C, ksub(TB) et ksub(b), l'inhibition de l'organification causee par le MMI

Additional details

Additional titles

Original title (French)
Cinetique precoce de l'iodure et du pertechnetate: elaboration d'un modele compartimental a partir de donnees obtenues a l'aide d'une camera a scintillation

Publishing Information

ISBN
2727200013
Imprint Title
17. French language symposium on nuclear medicine. Paris, June 2-4, 1975
Imprint Pagination
p. 114-117.
Report number
CEA-CR--3

Conference

Title
17. French language symposium on nuclear medicine.
Dates
02 Jun 1975.
Place
Paris, France.

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
7233478
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
COMPARTMENTS; GAMMA CAMERAS; IODIDES; IODINE 131; MATHEMATICAL MODELS; METABOLISM; PERTECHNETATES; SCINTISCANNING; TECHNETIUM 99; THYROID; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CAMERAS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; ENDOCRINE GLANDS; GLANDS; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE COMPOUNDS; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; OXYGEN COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM COMPOUNDS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
Imprint:17. Colloque de medecine nucleaire de langue francaise. Paris, 2-4 juin 1975.;Rapports et communications.