Synthesis and chromato-mass spectral investigation of labeled analogs of the antitumor preparation fotrin

The authors develop methods of synthesis of fotrin analogs labeled in the ethylenimine groups with radioactive carbon 14C and with deuterium and also a chromato-mass spectral investigation of the obtained compounds with the purpose of a subsequent deepened study of the pharmacokinetics and metabolism of fotrin. 14C-ethylenimine was obtained starting from 1,2-14C-dibromoethane. The mass spectra of the final product, 2H-fotrin, is shown. The intensities of the peaks of ions observed the mass spectra of fotrin and its deutero analog are presented as are the calculated ratios of isotopic peaks obtained on elimination of one and two ethylenimine groups from the molecular ion of deuterofotrin