Published December 2004
| Version v1
Journal article
Modulation of low-dose hyper-radiosensitivity, induced radioresistance and adaptive resistance by 2-deoxy-D-glucose in human glioma cell lines: implications for improving radiotherapy
- 1. Div. of Biocybernetics, Institute of Nuclear Medicine and Allied Sciences, Delhi (India)
- 2. International Center for Coordinated Research, Gurgaon (India)
Description
2-deoxy- D-glucose (2- DG) has been established as a potent adjuvant for enhancing efficacy of cancer radiotherapy due to its differential radiosensitization of tumour cells. In the present study, effects of 2-DG on low-dose hyper-radiosensitivity (HRS) and induced radioresistance (IRR) were investigated in two human glioma cell lines BMG-l and U87, which display increased sensitivity at gamma-radiation doses below 50cGy. This study demonstrates that hyper-radiosensitivity (HRS) and induced radioresistance (IRR) as well as the adaptive resistance induced at low doses can be effectively modulated by 2-DG in vitro
Additional details
Publishing Information
- Journal Title
- Indian Journal of Radiation Research
- Journal Volume
- 1
- Journal Issue
- 2
- Journal Page Range
- p. 16
- ISSN
- 0973-0168
Conference
- Title
- International conference on recent trends in radiation biology
- Dates
- 1-3 Dec 2004
- Place
- Mumbai (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 38031601
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- GAMMA RADIATION; GLIOMAS; GLUCOSE; LOW DOSE IRRADIATION; RADIOSENSITIVITY; RADIOTHERAPY; SURVIVAL CURVES
- Descriptors DEC
- ALDEHYDES; CARBOHYDRATES; DISEASES; ELECTROMAGNETIC RADIATION; HEXOSES; IONIZING RADIATIONS; IRRADIATION; MEDICINE; MONOSACCHARIDES; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; RADIATIONS; RADIOLOGY; SACCHARIDES; SENSITIVITY; THERAPY
Optional Information
- Notes
- Abstract prepared