Distribution of 123I , 99mTc - Human Polyclonal Nonspecific IgG and 67Ga - Citrate in Abscess bearing Mice

123I has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, 12'3I has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling condition of 123I and 99mTc to nonspecific human polyclonal IgG, and comparing these with 67Ga-citrate in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added 123I by chloramine T method. Human polyclonal nonspecific IgG was labeled with 99mTc-gluconate after activation with β-mercaptoethanol. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, 123I nonspecific IgG had higher uptake than 99mTc-IgG or 67Ga-citrate. There was no significant difference in abscess uptake of 123I-IgG among 24, 72, 120 hours abscess age. Further clinical researches with 123I-nonspecific IgG, and other immunoscintigraphies using 123I are expected.