Published March 1991 | Version v1
Journal article Metadata-only

Synthesis and radioprotective activity of 4-alkylthioethyl derivatives of pyridine

Creators

  • 1. Institut Biofiziki, Moscow (USSR)
  • 2. AN SSSR, Moscow (USSR). Inst. Organicheskoj Khimii

Description

Synthesis and study of toxic and radioprotective properties of 4-(2 alkylthioethyl)pyridines(1-12) and acid oxalates (13-18) of 1-3 and 5-7 compounds are carried out. It is shown that there are compounds among 4-alkylthioethyl derivatives, enabling survival of 60-100% of rats, subjected to irradiation dose LD84/30. Aqueous form of theses compounds - oxalates - do not possess radioprotective properties. The results obtained give grounds for continuation of serach of radioprotectors among pyridine thioderivatives

Additional details

Additional titles

Original title (Russian)
Синтез и радиозащитная активность 4-алкилтиоэтильных производных пиридина

Publishing Information

Journal Title
Khimicheskaya Fizika
Journal Volume
25
Journal Issue
3
Series
Khim. Fiz.
Journal Page Range
27-29
ISSN
0207-401X
CODEN
KHFID

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
23035029
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOSYNTHESIS; GAMMA RADIATION; LETHAL IRRADIATION; MICE; OXALATES; PYRIDINES; RADIOPROTECTIVE SUBSTANCES; SULFIDES; TOXICITY
Descriptors DEC
ANIMALS; AZINES; CARBOXYLIC ACID SALTS; CHALCOGENIDES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; SULFUR COMPOUNDS; SYNTHESIS; VERTEBRATES