Published February 1979
| Version v1
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Elastase-induced emphysema in guinea pigs
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Description
Pulmonary function changes measured in guinea pigs 4 to 5 wk following intratracheal instillation of crystalline porcine pancreatic elastase resembled comparable changes in humans with moderately severe pulmonary emphysema. Compared with saline-treated controls, elastase-treated animals had increased values for all divisions of lung volume, increased static compliance and prolonged time constants. Since humans with emphysema are especially sensitive to air pollutants, elastase-treated animals may be useful as sensitive animal models in inhalatio toxicology
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Additional details
Publishing Information
- Imprint Title
- Pacific Northwest Laboratory annual report for 1978 to the DOE Assistant Secretary for Environment. Part 1. Biomedical sciences
- Journal Page Range
- p. 1.8-1.10.
- Report number
- PNL--2850(Pt.1)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 10473238
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AIR POLLUTION; BIOLOGICAL FUNCTIONS; BIOLOGICAL MODELS; EMPHYSEMA; ENZYMES; EXPERIMENTAL DATA; GRAPHS; GUINEA PIGS; ISOLATED VALUES; LUNGS; PANCREAS
- Descriptors DEC
- ANIMALS; BODY; DATA; DATA FORMS; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; GLANDS; INFORMATION; MAMMALS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; POLLUTION; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES